what was the SG at? In order for it to be effective it needs to be way, way down like below 1.012. Also dont use medicines like copper or melafix with hypo.......causes too much stress. What was your ammonia at? Ammonia at any level is toxic especially to fish stressed with ich, hypo and medicated. Why was there ammonia in the tank? What type of filtration were you using and how frequent water changes were being done. Also what type of water stabelizer where you using. Like prime will bind the ammonia but if not removed by another water change will release it back into the system in a couple days Sorry for the loss.......however if this is the second ich outbreak then there is something going on in your tank leading to the stress and needs to be taking care of, like ammonia or something.