Dr Tim, I have used your product for FW before but am setting up my first SW aquarium. Back when I first learned of the "cycle" I used a bottle of One and Only and it was shipped to stores cold and stored cold. It worked and cycled my tank instantly. I think it was under a different name back then but do not recall for sure, I remember the store telling me it was the same product but something to do with patents and what not. My second experience with your product was many years later and the bottle was what it appears to be today, this was for another smaller tank that had been stuck in a cycle with high ammonia and 0 nitrite. I dosed several times and never did it work, when asking about it I was told the stores no longer got in shipped cold because it no longer needed to be kept cold and many aquarists expressed concern that it no longer worked nearly as good as it did originally. I struggled for a month with this tank using all kidns of promised products and doign WC to keep ammonia levels down and the only thing that finally broke the cycle was adding biowheels for a filter and using old nasty filter media and filter water from a LFS. Question is, how does t his stuff work for SW as opposed to FW? I am hoping the second time I used this stuff it was jsut a bad batch since the lfs does store it in a fridge but does not get it shipped in a cold pack. When it did work the first time it was great, I do not want an empty SW tank for a month and my wife wants to go out an get "Nemo" ASAP but I do not want to torture the guy with a crazy cycle. I set up a 46gallon SW tank with all dry rock, was a little dirty so it should have some organics but not much, and Caribsea Ocean Direct Live sand in a bag. I plan on getting a few pieces of LR rubble from a lfs and was thinking abotu giving your product a second chance. Is it safe to add the LR, one and only, and nemo all at once?