I would always run a skimmer 24/7 it will not pull out anything that would otherwise create problems.
Most skimmers need a break in period. It usually means you have to dial down the air intake because the foam is too much and it will flood. Or the opposite it does not skim much at all.
After the 72 hours you should then begin adjusting the air and water levels to achive the skimming you want
J |